Phosphodiesterase-Type 5 and the active ingredient in Levitra

Having a good erection requires adequate stimulation and a good supply of cGMP (cyclic guanosine monophosphate). Stimulation is required for the active ingredient of Viagra or Levitra to work. Some mischievous college boys sometimes put a diamond-blue pill on their dorm mates’ drink or their dorm master’s cup of coffee to find out whether the blue pill really works. However, they often ended up disappointed because the “pill” failed to produce the desired results. This is simply because the active ingredient does not work in the absence of an adequate stimulation.

The second important factor is the supply of cGMP in the blood. This substance causes the smooth muscles in the penile blood vessels to relax and this produce an excellent blood supply to the penis. If the supply is low, then the man could not maintain his erection or fail to develop one. PDE5 (Phosphodiesterase Type 5) are very specific enzymes such that they attack and degrade cGMP. As more cGMP-PDE5 complexes are being circulated in the bloodstream, there will be lesser free cGMP in the circulation. Vardenafil found in Levitra and sildenafil citrate found in Online Viagra are substrates that bind with PDE5. The creation of these new substrates removes the obstructions that hinder cGMP to perform its tasks. Now, smooth muscle relaxation and blood flow could go on smoothly.

When you buy Cialis online, the mechanism is almost the same. Cialis, like its younger sister Levitra and its older brother Viagra, is a PDE5 inhibitor. However, among the three known inhibitors, Cialis has the longest half life. The other two have an average half life of 4.5 while Cialis has a known average half-life of 17.5 hours. Thus, many recommend the pill if someone goes for a long honeymoon or a weekend vacation.

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